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in Allgemeine Methoden 05.01.2019 13:07
von mariareese • 4 Beiträge | 4 Punkte

Tramadol is used similarly to codeine, to treat moderate to moderately severe pain. Tramadol is somewhat pharmacologically similar to levorphanol (albeit with much lower μ-agonism), as both opioids are also NMDA-antagonists which also have SNRI activity (other such opioids to do the same are dextropropoxyphene (Darvon) & M1-like molecule tapentadol (Nucynta, a new synthetic atypical opioid made to mimic the agonistic properties of tramadol's metabolite, M1(O-Desmethyltramadol). Tramadol is also molecularly similar to venlafaxine (Effexor) and has similar SNRI effects, with antinociceptive effects also observed.

If you have Crohn’s disease, colitis, or hemorrhoids you shouldn’t consume aloe. It can cause severe abdominal cramps and diarrhea. You should stop taking A. vera if you’re taking other drugs. It may decrease your body’s ability to absorb the drugs.

People who are suicidal or prone to addiction should not take tramadol. Those with a history of emotional disturbances (including depression or alcohol abuse) should consider taking non-narcotic analgesics instead. Because tramadol increases the amount of serotonin in your brain, you may be at risk for a condition called serotonin syndrome if you combine tramadol with other medications that also raise serotonin levels, especially antidepressants.

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